Crossed Aldol Condensation Reactions in the Presence of Potassium Fluoride Supported on Activated Alumina-neutral

Tomoki HONDA; Jun IKEMOTO; Kazuhiko EDA; Takeo KURATA

doi:10.5650/jos1996.46.57

Tomoki HONDA, Jun IKEMOTO, Kazuhiko EDA, Takeo KURATA

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Keywords: crossed aldol condensation, solid base catalyst, potassium fluoride supported on activated alumina-neutral

JOURNAL FREE ACCESS

1997 Volume 46 Issue 1 Pages 57-62

DOI https://doi.org/10.5650/jos1996.46.57

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Abstract

Crossed aldol condensation reactions are indispensable to the formation of C-C bonds in organic synthesis.
Examination was made of these reactions between benzaldehyde (1) and 2-butanone (2) using as solid base catalysts several fluoride salts supported on various inorganic solids.
Potassium fluoride supported on activated alumina-neutral (KF/A₂O₃-neutral) was found to be a factor in the crossed aldol condensation of 1 with 2. By this catalyst, various aromatic aldehydes with ketones could be used in the synthesis chalcones and distyryl ketones.

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