抄録
Buprofezin (2-tert-butylimino-3-isopropyl-5-phenylperhydro-1, 3, 5-thiadiazin-4-one) exhibits an effect regulating the growth of homopterous insect pests. In the steps to buprofezin, we synthesized a variety of dithiazines and thiadiazines to investigate their biological activities by the long-term observation. Some perhydrothiadiazines were first found to show the nymphicidal activity during the molting on Nilaparvata lugens STÅL. From the structure-activity relationships, the 2-imino group was seemed to be crucial for high nymphicidal activity. Introduction of an aromatic substituent onto the 5-position, especially non-substituted phenyl group, was most effective for the activity. The action of finally selected buprofezin on N. lugens were characteristic: (1) species specificity; (2) the high molt-inhibiting action through chitin biosynthesis inhibition; (3) the short longevity of adults; (4) the suppressive oviposition, and (5) the deposition of unhatchable eggs. Thus, buprofezin is considered to be an insect growth regulator rather than an insecticide.
