Involvement of the Na+/Ca2+ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400

Iyuki Namekata; Yayoi Tsuneoka; Akira Takahara; Hideaki Shimada; Takahiko Sugimoto; Kiyoshi Takeda; Midori Nagaharu; Koki Shigenobu; Toru Kawanishi; Hikaru Tanaka

doi:10.1254/jphs.08159SC

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Involvement of the Na⁺/Ca²⁺ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400

Iyuki Namekata, Yayoi Tsuneoka, Akira Takahara, Hideaki Shimada, Takahiko Sugimoto, Kiyoshi Takeda, Midori Nagaharu, Koki Shigenobu, Toru Kawanishi, Hikaru Tanaka

著者情報

キーワード: pulmonary vein myocardium, Na⁺/Ca²⁺ exchanger, automaticity

ジャーナルフリー早期公開

論文ID: 08159SC

DOI https://doi.org/10.1254/jphs.08159SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 110 (2009) , No. 1 p.111

詳細

抄録

We examined the involvement of the Na⁺/Ca²⁺ exchanger in the automaticity of the pulmonary vein myocardium with a specific inhibitor, SEA0400. Action potentials were recorded from the myocardial layer of isolated guinea-pig pulmonary vein preparations, and Ca²⁺ transients were recorded from the cardiomyocytes. Spontaneous electrical activity was observed in 17.7% of the preparations, which was inhibited by either SEA0400 or ryanodine. In quiescent preparations, ouabain induced electrical activity and spontaneous Ca²⁺ transients, which were inhibited by SEA0400, as well as ryanodine. These results provide pharmacological evidence that the Na⁺/Ca²⁺ exchanger underlies the automaticity of the pulmonary vein myocardium.

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