A Novel Chemoattractant Lectin, Karatoxin, From the Dorsal Spines of the Small Scorpionfish Hypodytes rubripinnis

Mitsuko Shinohara; Kuniko Nagasaka; Hideyuki Nakagawa; Kozue Edo; Hitomi Sakai; Koji Kato; Futoshi Iwaki; Kiyoshi Ohura; Haruhiko Sakuraba

doi:10.1254/jphs.10058SC

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A Novel Chemoattractant Lectin, Karatoxin, From the Dorsal Spines of the Small Scorpionfish Hypodytes rubripinnis

Mitsuko Shinohara, Kuniko Nagasaka, Hideyuki Nakagawa, Kozue Edo, Hitomi Sakai, Koji Kato, Futoshi Iwaki, Kiyoshi Ohura, Haruhiko Sakuraba

著者情報

キーワード: chemoattractant lectin, Karatoxin, Hypodytes rubrinnis

ジャーナルフリー早期公開

論文ID: 10058SC

DOI https://doi.org/10.1254/jphs.10058SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 113 (2010) , No. 4 p.414

詳細

抄録

A chemoattractant lectin from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis, was isolated using a combination of affinity chromatography techniques. The glycoprotein, with a molecular mass of 110 kDa, is named Karatoxin. Karatoxin caused agglutination of rabbit erythrocytes. This agglutination was effectively inhibited by D-mannose. In addition, Karatoxin exhibited not only mitogenic activity in the presence of murine splenocytes, but also chemotactic activity in the presence of guinea-pig neutrophils and macrophages. Thus, Karatoxin appears to be a novel chemoattractant lectin. These results suggest that the redfin velvetfish Hypodytes rubripinnis may be a novel source of biologically active substances.

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