抄録
The response to [Sar1, ile8] angiotensin II (A II A) infusion during sodium depletion and the longterm effect of SQ14, 225 were compared between seven hypertensives with unilateral (US) and four with bilateral renal artery stenosis (BS). Plasma renin activity (PRA) was significantly higher in US than BS during both sodium depletion and repletion. A fall in diastolic blood pressure induced by AIIA infusion was more marked in US than in BS. The ratio of renal venous renin during sodium depletion was significantly higher in US (1.68±0.08) than in BS (1.19±0.08) and was negatively correlated with a fall in diastolic blood pressure induced by A II A infusion. SQ14, 225 showed the same degree of hypotensive effect in US and BS after one month administration. PRA rose and plasma aldosterone decreased equally in US and BS during treatment. There were no significant correlations between the reduction of blood pressure during treatment with SQ14, 225 and pretreatment PRA levels or changes of diastolic blood pressure observed during A II A infusion. These results indicate that the mechanism maintaining high blood pressure is more renin dependent in US than in BS and that the long-term effect of SQ14, 225 might not depend solely on the suppression of renin-angiotensin-aldosterone system.
