抄録
We experienced two cases of limb edema of unknown pathogenesis. No evidence was found concerning involvement of the kidneys, heart of other visceral organs. Case I was 22-year-old woman. Her white blood cell count increased to 13, 100/μl with 65.0 % eosinophils. Case 2 was a 27-year-old woman. Her white blood cell count increased to 23, 300/μl with 67.0 % eosinophils. In these cases, extensive diagnostic evaluations revealed no evidence of atopy, neoplasms, collagen vascular disease, or parasitic infestation. We diagnosed these cases as episodic angioedema with eosinophilia. In both cases, the angioedema improved gradually in parallel with a decrease in the white blood cell count. This disorder is very rare, but it is very important to consider it in differential diagnosis especially for nephrologists.
