The Journal of Poultry Science
Online ISSN : 1349-0486
Print ISSN : 1346-7395
ISSN-L : 1346-7395
Environment and Management
Oral Administration of D-aspartate, but not of L-aspartate, Reduces Food Intake in Chicks
Edi ErwanShozo TomonagaTaketo OhmoriYuta MutaguchiToshihisa OhshimaMao NagasawaShinobu YasuoYoshinaga TamuraMitsuhiro Furuse
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2013 Volume 50 Issue 2 Pages 164-171


In the present study, we determined the effects of oral administration of L- and D-aspartate (L-Asp and D-Asp) on food intake over a period of 2 h after the administration, as well as its effects on the concentration of L- and D-Asp in the brain and plasma. Chicks were orally administered different levels (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-Asp (Experiment 1) and D-Asp (Experiment 2). Administration of several doses of L-Asp linearly increased the concentration of L-Asp, but not of D-Asp, in plasma. Oral L-Asp somewhat modified the levels of L- and D-Asp levels in the telencephalon, but not in the diencephalon. However, food intake was not significantly changed with doses of L-Asp. On the other hand, D-Asp strongly and dose-dependently inhibited food intake over a period of 2 h after the administration. Oral D-Asp clearly increased D-Asp levels in the plasma and diencephalon, but no significant changes in L-Asp were detected. Brain monoamine contents were only minimally influenced by L- or D-Asp administration. We conclude that D-Asp may act as an anorexigenic factor in the diencephalon.

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© 2013 by Japan Poultry Science Association
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