Influence of Supernatants from Rabbit Luteal Tissue Cultures on Blastogenesis of Peripheral Blood Lymphocytes

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To evaluate the correlation between luteolysis and T lymphocytes (T-cells) found in the corpus luteum (CL), peripheral blood lymphocyte (PBL) blastogenesis to mitogens tested for the presense of luteolytic factor(s) in the supernatant culture medium of luteal tissues from various stages of pseudopregnancy (PSP). PBL blastogenesis was measured by ³H-thymidine uptake. The culture medium of luteal tissue from Day 15 PSP caused a significantly high ³H-thymidine uptake in the Con A stimulation group of the PBL blastogenesis test. The present finding suggests the presence of some factors which activate in the regressive CL.