Journal of Reproduction and Development
収録数 3,677本
(更新日 2020/08/09)
Online ISSN : 1348-4400
Print ISSN : 0916-8818
ISSN-L : 0916-8818
ジャーナル 査読 オープンアクセス 早期公開
Scopus Pubmed
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66 巻 (2020) 3 号 p. 277-280
An investigation of the time period within which frozen-thawed semen delivers a high conception rate in lactating dairy cows もっと読む
66 巻 (2020) 2 号 p. 105-113
Increased supply from blood vessels promotes the activation of dormant primordial follicles in mouse ovaries もっと読む
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Cover Story:
Most primordial follicles present in ovaries are dormant and only a few of them are activated in every estrus cycle. However, the mechanism controlling the activation of dormant primordial follicles in vivo remains unclear. In this study, Komatsu et al. found that almost all the activated primordial follicles (black arrows) made contact with blood vessels (red arrows) in mouse ovaries (Komatsu et al. Increased supply from blood vessels promotes the activation of dormant primordial follicles in mouse ovaries. pp. 105–113). To confirm the hypothesis that angiogenesis is crucial for activation of the dormant primordial follicles in vivo, Komatsu et al. induced angiogenesis using recombinant VEGF. They found that the activation of dormant primordial follicles was promoted by an increase in the number of blood vessels in the ovaries. Furthermore, the number of activated follicles increased in cultured ovarian tissues depending on the serum concentration in the medium. These results confirm that the supply of serum components through new blood vessels formed via angiogenesis is a cue for the activation of dormant primordial follicles in the ovaries.

66 巻 (2020) 1 号 p. 67-73
Production of mouse offspring from inactivated spermatozoa using horse PLCζ mRNA もっと読む
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Improving artificial oocyte activation is essential for animal biotechnology, to obtain healthy offspring with a high success rate. Yamamoto et al. investigated whether the equine sperm-specific phospholipase C zeta (ePLCζ) mRNA, which has the strongest oocyte activation potential in mammals, could improve the mouse oocyte activation rate and subsequent embryonic development using inactivated spermatozoa (Yamamoto et al. Production of mouse offspring from inactivated spermatozoa using horse PLCζ mRNA. pp. 67–73). The activation potential of ePLCζ was ten times greater than that of murine (m) PLCζ and normal blastocysts were obtained. However, the birth rate was slightly, but significantly, decreased in oocytes activated by ePLCζ compared to those activated by mPLCζ. These results suggest that activation rate does not always correlate birth rate.

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