Journal of Reproduction and Development
Online ISSN : 1348-4400
Print ISSN : 0916-8818
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Effect of Pueraria mirifica on the Sexual Skin Coloration of Aged Menopausal Cynomolgus Monkeys
Hataitip TRISOMBOONSuchinda MALAIVIJITNONDWichai CHERDSHEWASARTGen WATANABEKazuyoshi TAYA
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2006 年 52 巻 4 号 p. 537-542

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To investigate the estrogenic effect of Pueraria mirifica (PM), a Thai herbal plant that contains many phytoestrogens, sexual skin coloration was studied in cynomolgus monkeys. Aged menopausal monkeys were divided into three groups. Each group (n=3) was fed 10, 100, or 1,000 mg of PM daily. The treatment schedule was divided into three periods, a 30-day pre-treatment period, 90-day treatment period, and 60-day post-treatment period. The results show that the sexual skin exhibited reddish coloration within 24 h after PM-treatment and remained this way for the first half of the PM-feeding period. The changes in sexual skin coloration were not dose-dependent. The present results indicate that PM had estrogenic action by increasing reddish sexual skin coloration in aged menopausal monkeys.

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