下垂体別出幼若雌鼠の生殖器系に及ぼす最少有効量のFSHと種々な量のICSHの同時投与成績

抄録

Effects of the combined treatment with the minimal effective dose of purified swine FSH (200γ) and the various levels of purified sheep ICSH (LH) on the ovaries and the uteri of hypophysectomized immature female rats were studied. The experimental conditions were the same as that of the previous report⁵⁾ except that FSH and ICSH were injected separately into the underskin at different sites of the body.
On injection of 200γ of FSH alone, ovaries and uteri were increased in weight. This dose of FSH caused the development of follicles with stimulated internal theca cells and without repair of the deficient interstitial cells. The ovarian and uterine weights were barely increased by the large dose (1 mg) of ICSH. The most conspicuous effect of ICSH was the stimulation of the interstitial tissue. The augmentation of the effect of 200γ of FSH on the increase of ovarian and uterine weights was not conspicuous by combination with ICSH. The histological examination demonstrated that the interstitial tissue was highly stimulated and the follicular growth with the development of internal theca cells was somewhat augmented, but no thecal luteinization nor formation of corpus luteum was detected. The stimulative effect of FSH on estrogen secretion, estimated by the uterine development, was not so increased by the combined treatment of ICSH. The authors (1957) found that FSH is the potent substance to induce ovulation in adult rats⁸⁾.
By these results, it would be said that the main effect of ICSH on the ovary may be the stimulation of interstitial tissue, and FSH might play more important role to cause the formation of corpus luteum.