Purpose: To evaluate the relationship between 18F-FDG uptake and expression of glucose transporters (Gluts) and hexokinase II (HK II) in hepatic tumors.
Materials and Methods: This study included 31patients with HCC and 26 patients with CCC. All patients underwent to whole body 18F-FDG PET and CT examinations before treatment. PET acquisition was started at 60 minute after the injection of 18F-FDG (5-6 MBq/kg) Semiquantitative analysis using standardized uptake value (SUV) was measured for evaluation of tumor 18F-FDG uptake. Diagnosis were conformed by histological examination. Immunohistochemical staining of the section for glucose transporter 1, 2, 3, 4, 5 and HK II were performed using the streptoavidin-biotin methods.
Results: Immunohistochemistry activity were detected in Glut 1,Glut 2 and HK II in HCC where Glut 1, Glut 2 , Glut 3 and HKII in CCC. Gluts and HK II were often detected in moderately differentiated and poorly differentiated than well differentiated HCC. Significant association was revealed between the FDG uptake and expression of Gluts and HK II in HCC and CCC Conclusion: Present study showed significant association between 18F-FDG uptake and expression of Gluts and HK II in HCC and CCC even though 18F-FDG uptake was different, indicating that present finding may be valuable in management of both type of hepatic tumor.
