大気圧低温プラズマが皮膚損傷の治癒機序に与える影響

抄録

　The skin plays a protective role against various environmental stimuli. Promoting healing is extremely important because failure to heal leads to a decline in QOL. Current treatments for skin wounds have side effects such as skin atrophy and drug allergies, so there is a need for less invasive treatments. In recent years, medical applications of atmospheric low temperature plasma (ALTP) have been promoted. Skin wound treatment is one of these uses. In this study, we investigated the effects of ALTP on skin injuries by shortening the healing time of ALTP treatment and analyzing gene expression using RT-qPCR. ALTP irradiation was shown to increase the expression levels of IL-6 and HIF-1α during the inflammatory phase. These results suggest that ALTP promotes healing in wound tissue during the inflammatory phase via inflammatory cytokines and hypoxia-inducible factors.