XAD-4 is copolymer of styren-divinyl benzene with adsorbability for lipid-soluble and protein-bound substances, , being one of the most promising among various adsorbents for hepatic support.
To improve the blood compatibility, the acetylated chitin coating of the XAD-4 which is named HNC-X has been adopted and evaluated adsorbability for serum bilirubin by 2 hours direct hemoperfusion (DHP) in dogs with obstructive jaundice.
In vivo studies of DHP revealed HNC-X was effective to improve the blood compatibility and the adsorption for serum bilirubin.
Platelet count was returned to the normal range by the end of the 2 hours DHP with HNC-X.
Based on these studies, acetylated chitin coated XAD-4 (HNC-X) is believed to be available for the liver failure as hepatic assist.
