Despite the dramatic advance of medical polymeric material, we can not get yet the clinical available material with high antithrombogenicity. Under this situation, we devised the urokinase-treated Evatate intravenous catheter for total parenteral nutrition. This report presented the possibility of clinical application of our catheters, on which urokinase was immobilized by the differential conditions of pH in urokinase solution.
The results are as follows:
1) They, 1.5mm in outer diameter and 40cm in length, have the fibrinolytic activity of 10.6±0.8 units/10cm of tube in pH 6.0 prepared catheter and 36.6±1.9 units/10cm of tube in pH 4.0 prepared catheter.
2) These activities gradually decreased after the intravenous catheterization and reached to the level of 3.9-1.7 units/10cm of tube after one week.
3) They showed the excellent antithrombogenicity in clinical trials and the thrombus formation was observed in no more than 10% of all catheters.
We suppose that this technique could be utilized in many kind of medical fields.
