1981 年 10 巻 6 号 p. 993-996
The polymer with the long PEO chains (PVC-g-M100G) was synthesized by graft-copolymerization of methoxypolyethyleneglycolmethacrylate to polyvinylchloride. The effect of the long PEO chains on the antithrombogenicity was investigated in in vitro and in vivo. In vitro studies revealed that the PEO chains which protract from the surface into blood phase effectively prevent the platelet adhesion and protein adsorption due to the effect of volume restriction repulsion. On the surface of PVC-g-M100G implanted in the jugular and femoral veins, neither platelet adhesion nor fibrin deposition was observed for up to 72 days. Furthermore, transmission electron microscopic studies showed the plasma proteins adsorption via the long PEO chains.