抄録
Separation of plasma from whole blood using either cell centrifuge or membrane filtration has had an increasing application for treatment of various disease states. Separation rate and the quality of separated plasma during a limited time period are of primary importance for clinical applications. Plasma separation by means of membrane filters is a process during which membrane properties are changing. This is caused by a) deposition of formed blood particles at the surface of the membrane as a result of a dragging force created by filtration; b) entrapment and possible sorption of proteins, lipoproteins and other macromolecules within the structure of the membrane pores; c) gelation on the surface of the membrane of proteins and other substances for which sieving coefficient is less than one, and d) clotting mechanisms. Considering these factors, various plasma separators has been evaluated in in vitro, ex vivo and clinically, showing that membrane plasma separation is promising and can be best operated at the lowest possible transmembrane pressure to prevent serious deterioration of filtration properties.
