Abstract
Prostaglandin (PG) D2 was evaluated as an antiplatelet agent for hemodialysis by dialyzer clearances.
Simultaneous administration of 100μg/hr PGD2 and 1, 000U/hr heparin was compared with 1, 000U/hr heparin as regards platelet counts, plasma β-thromboglobulin (β-TG) levels and dialyzer clearances.
In both groups, transiently decreased platelet counts returned to initial levels within one hour after the start of hemodialysis. Plasma β-TG levels were significantly increased by hemodialysis in heparin group, but not in PGD2 group. In PGD2 group, declines of dialyzer clearances observed in heparin group were significantly prevented.
These data indicate that PGD2 is a usefull antiplatelet agent for hemodialysis.
