Abstract
The present study was de signed to examine the effect of ultraf iltration (U-F) on tissue water content in small intestine (TWC), in dog, during hemodilution cardiopulmonary bypass (CPB). Eight dogs were placed on 5 hours' PB. The loss of the circulating blood volume was compensated by adding lactated Ringer's solution to the perfusate as required to maintain the level in the reservoir. After the first 2 hours' CPB, five dogs (group I) underwent U-F with blood transfusion for 2 hours. The remaining three dogs (group II) did not receive U-F. After the first 2 hours, hematocrit (Hct), serum total protein (TP) and serum colloid oncotic pressure (COP) were reduced arid. TWC increased in both groups. The difference between serum COP and lymphatic COP in thoracic duct markedly decreased. For the second 2 hours, in group I, Hct, TP and serum COP were elevated and the difference in COP was enlarged. Simultaneous reduction in TWC was obtained. In group II, Hct, TP and serum COP remained low and TWC increased. The results suggested that U-F might be effective to prevent from increase of TWC during hemodilution CPB.
