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[in Japanese]
1983 Volume 12 Issue 2 Pages
377
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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[in Japanese]
1983 Volume 12 Issue 2 Pages
379-381
Published: April 15, 1983
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K. MIYAMURA, H. SHINPO, M. NASU, S. SHOMURA, I. YADA, M. KUSAGAWA
1983 Volume 12 Issue 2 Pages
382-385
Published: April 15, 1983
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We have developed an electromechanical left ventricular assist device which is driven by solenoids, and evaluated it in vivo using dogs. The device was connnected to the left atrium and the descending aorta, then settled on the chest wall. The maximun flow rate of 2.3L/min was gotten under 2:1 synchronous driving. We found the device sometimes did not respond to the left atrial pressure, and sometimes it competed with the natural hearts because of its relatively long ejection time to the R-R interval of them. Many problems are left to be resolved for us, those are, how to evaluate the device in vivo, how to make it more powerfull and smaller and so on.
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I. FUJIMASA, K. IMACHI, A. MIYAMOTO, K. ATSUMI
1983 Volume 12 Issue 2 Pages
386-389
Published: April 15, 1983
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A new designed cardiac ventricular assist device system for clinical use, which consists of two blood pumps and a driving control unit, has been developed and evaluated in vitro and in vivo. The blood pump is a sac type with two B-S valves. The pump and two cannulae are made of PVC coated by Cardiothane. The driving unit is an air driven type and the size is very compact (77cm wide, 47cm deep and 110cm high). Driving conditions can be changed by the remote controller from surgical field.
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H. TAKANO, Y. TAENAKA, T. MATSUDA, M. UMEZU, T. NAKAMURA, K. HAYASHI, ...
1983 Volume 12 Issue 2 Pages
390-394
Published: April 15, 1983
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The modified new blood pump is made of highly antithrombogenic and durable Japanese make polyurethane (PU), of which stroke volume is 70ml and the maximum output is 7L/min. It was discovered that thrombus was not formed inside the pump without anticoagulant provided in the first several days flow was kept more than 2L/min. It is thought that the mechanism of acquiring excellent antithrombogenicity is due to biolization of the PU surface by protein deposition. Since up to present study thrombus was not formed for at least one month, the authors are convinced that our blood pump can be safely used for temporary clinical situation.
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Y. TAENAKA, T. MATSUDA, H. TAKANO, M. UMEZU, K. HAYASHI, T. NAKAMURA, ...
1983 Volume 12 Issue 2 Pages
395-399
Published: April 15, 1983
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Changes of coagulation parameters after implantation of left ventricular assist device (LVAD) were examined in five goats. Blood contact surface of LVAD was coated with segmented polyurethane (TOYOBO, TM-3). Heparin was used only during implantation surgery and no anti-coagulant therapy was done postoperatively. Fibrinogen and Prekallikrein decreased during the first three postoperative days (POD). Then fibrinogen showed a rebound increasing above the control level and prekallikrein came back to the control level. Prothrombin time and partial thromboplastin time prolonged between 2nd and 5th POD. FDP appeared on around 2nd POD and had its peak between 5th and 7th POD. Platelet aggregation induced by ADP decreased postoperatively and remained low in late postoperative days.
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J. SAKURAI, H. MAETA, T. ITOH, M. HORI
1983 Volume 12 Issue 2 Pages
400-403
Published: April 15, 1983
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The hemodynamic effect of the right heart assist with a newly designed intraatrial triple balloon pumping (IAtBP) was evaluated, using the right ventricular bypass model in mongrel dogs. All the studies were done in severe shock state of the blood pressure about 50mmHg. The IAtBP significantly increased cardiac output and mean aortic pressure by 27% and 11% respectively, and also reduced mean right atrial pressure by 28%. We considered that the hemodynamic improvement by the IAtBP might be concluded that this “Intraatrial Triple Balloon Pumping” was useful for the right heart assist.
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Y. SUGITA, H. KUME, K. MARUYAMA, Y. NAKAMURA, H. EMOTO, K. MORITA, K. ...
1983 Volume 12 Issue 2 Pages
404-407
Published: April 15, 1983
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This study is aimed to evaluate the effect of IABP on pulmonary circulation in the state of LOS after open heart surgery. We measured COP-PAWP gradient, extravascular lung water (EVLW), PVR, A-aDO
2, Qs/Q
T, and Respiratory Index. The following results were obtained. The change of COP-PAWP gradient, A-aDO
2 and EVLW reflected the effect of IABP on pulmonary circulation in the state of LOS.
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[in Japanese]
1983 Volume 12 Issue 2 Pages
408
Published: April 15, 1983
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T. WATANABE, K. YAGATA, T. UCHIMA, J. YAMAUCHI, R. KUSABA, O. OTSUBO
1983 Volume 12 Issue 2 Pages
409-412
Published: April 15, 1983
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We have been making the experiments about implantable artificial kidney; and deviced a system that filtration and reabsorption function of kidney is carried out by hemofilter and alimentary tract.
This time, we could control the increace of uremic toxins using adsorbents jointly. Filtrate from the polysulfon or polyacrylonitryl hemofilter and adsorbents (Zirconium phosphate, Activated charcoal and Zilconium hydroxide) were injected to the duodenum catheter. Consequently, BUN and serum creatinine were controled less than 100mg/dl and 4mg/dl. Readsorption of water was satisfactoly, thus diarrhea was once in a day. This method is expected the triple effect, i. e. adsorption of uremic toxins in digestive fluids, hemoperfusion through the intestines mucosa, and purificarion of filtrate.
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T. WATANABE, M. NOMURA, T. UCHIMA, K. YAGATA, O. OTSUBO, S. TAKAI, H. ...
1983 Volume 12 Issue 2 Pages
413-416
Published: April 15, 1983
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Artificial kidney with sorbent regeneration of dialysate has been developed to miniaturized dialysis system in our laboratory. We developed a new type of macro-polus activated charcoal for the purpose of removal of creatinine from within dialysate. This material is made of superior coal, its mean diameter ranging 0.55mm, the effective surface area being 1240m
2/gr and macro-polus being (less than) 0.645 cc/gr. In present study, in vitro and vivo adsorption of creatinine, Vit. B
12 and amino acids including Tyr, Phe, Met, Val, Leu and Isoleu, were tested with this material. It was concluded that the macro-polus activated charcoal was superior in adsorbab ility to conventional charcoal.
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F. KANAI, T. TAKAHAMA, I. IIZUKA, Y. TANAKA, K. YABE, M. HIRAISHI, Z. ...
1983 Volume 12 Issue 2 Pages
417-420
Published: April 15, 1983
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Models of chronic renal failure were made on dogs by the ligation of the second branch of lt. renal artery combined with rt. nephrectomy, preserving the 1/8 remnant kidney over all, and they were treated with oral adsorbent (AST-120) postoperatively. They showed increase in serum creatinin and BUN levels, but during the administration of the oral adsorbent, an improvement was observed to some extent, regarding crestinine, BUN levels, creati nine clearance and capacity of PSP excretion, and the mortality rate was diminished remarkably. On the other hand, High Performance Liquid Chromatography revealed abnormal peaks such as seen in patients of chronic renal failure, but the appearance of those peaks were inhibited during the administration of the adsorbent and this may indicate adsorption of unknown uremic metabolites including so-called “uremic toxin” by the oral adsorbent play an important role in the improvement of renal function.
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-Adsorptive therapy for phosphate-
K. TAMURA, H. KOJIMA, K. MORIKAWA, H. KIMUGASA, T. SEKIGUCHI, F. NAKAY ...
1983 Volume 12 Issue 2 Pages
421-424
Published: April 15, 1983
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We previously reported that direct hemoperfusion (DHP) with zirconium microcapsule could be beneficial thrapeutic procedure to remove phosphate (P) in the model of acute renal faalure dogs. In those experiments, Zr oxied also adsorbed calcium and calcium level fell significantly during DHP. To resolve the problem, we newly developed Ca-Zr-carbonate which did not adsorb calcium and could release carbonate in exchange for P. In invitro study, Ca-Zr-carbonate showed same adsorprive capacity for P as Zr oxide. P level decreased remarkably during DHP in acute renal failure dogs with 60g of Ca-Zr-carbonate, but no changes were observed in calcium concentration. Zr did not interfere the adsorptive capacity of charcoal and charcoal did not have any adverse effects on that of Zr. Zr was not detected in serum after the one week incubation with Zr microcapsule. These results indicate that DHP with Ca-Zr-carbonate can be safely applicable to treat not only hyperphosphatemia, but also uremia in combination with other adsorbents such as charcoal. It can be said that Ca-Zr-carbonate is very useful adsorptive material for uremia.
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A. YAMASHITA, T. YOSHIMOTO, K. ANDO, K. YOSHIMOTO, H. HIDAI, T. SAKAI, ...
1983 Volume 12 Issue 2 Pages
425-428
Published: April 15, 1983
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Cellular membrane clearance (K
C) and fluid volume ratio in intra and extra cellular (V
I:V
E) are closely related with the change of solute concentration in the blood purification therapy. K
C, which is obtained in this paper using HF, is larger than that of some previous reports. (V
I:V
E) has a much larger effect on the concentration change in uric acid than in urea or crest inine.
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C. OYAMA, D. J. MAGILLIGAN, K. KAWACHI, S. KOH, S. KITAMURA
1983 Volume 12 Issue 2 Pages
429-432
Published: April 15, 1983
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Ultrafiltration (UF) will be used usually for hemodialysis as an artificial kidney, and its effect is remarkable in removal of excess water. In this experiment, however, it was used alone to remove overfluid in mongrel dogs during cardiopulmonary bypass (CPB) for two hours. Four dogs were without UF, and the other ones were with UF during 2-hour bypass. Each dog was done hemodynamic studies, and measured extravascular lung water (EVLW). The “UF” group showed remarkable results in hemodynamic studies and EVLW after 2-hour CPB.
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[in Japanese]
1983 Volume 12 Issue 2 Pages
433
Published: April 15, 1983
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Y. SHIRAISHI, S. MURATA, N. NISHIWAKI, T. MURAKUCHI, Y. CHIBA, A. YAMA ...
1983 Volume 12 Issue 2 Pages
434-440
Published: April 15, 1983
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Changes in free plasma hemoglobin during extracorporeal circulation was investigated on 152 cases who had undergone cardiopulmonary bypass in these seven years. It was demonstrated that there was no decrease in free plasma hemoglobin in these three years in comparison with that in the earlier four years. Some kind of perfusion techniques such as operative. field suction under low pressure should be used to prevent hemolysis.
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Harunori TAKEDA, Hiroyoshi MATSUKURA, Toshiaki KAWAKAMI, Tatsuzo TANAB ...
1983 Volume 12 Issue 2 Pages
441-444
Published: April 15, 1983
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In 16 mongel dogs, 2 hour total cardiopulmonary bypasses were carried out with Hollow-fiber oxygenators and bubble oxygenators for evaluation of platelet function and circulatory status. Adequet oxygenation and carbon deoxide elimination were observed with Hollow fiber oxygenators in spite of low ratio of oxygen flow to blood flow.
Plasma free hemoglobin level was low throughout perfusion compared to bubble oxygenators with Hollow fiber oxygenators. Platelet kinetics were elevated during perfusion. It seems to suggest that platelets in active stage are brought back into circulatory blood by detachment or deaggultination.
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S. MURATA, T. IWA, T. MEKATA, M. HORITA, K. MATSUURA
1983 Volume 12 Issue 2 Pages
445-448
Published: April 15, 1983
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When laser beam radiates the microairbubble in the cell, the change of the intensity of laser beam is observed.
The hematocrit value is kept 20, 25 and 30 percents. In case of the size of microairbubble is about 50 to 200μm in diameter, the upward spike wave is observed in the transient recording.
When the diameter of microairbubble is increased into 200 to 250μm, the three different spike waves are observed, namely upward-downward, upward-downward-upward and downward-upward. In the case of the microairbubble above 250μm in diameter, the spike wave is downward. Thus, the microairbubble in the diluted blood in the extracorporeal circuit is confirmed to be identified by the laser detector.
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T. TSUJI, T. TAMURA, T. TOGAWA, Y. KOYAMA, H. KANEKO, J. NARUMI, K. SU ...
1983 Volume 12 Issue 2 Pages
449-452
Published: April 15, 1983
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The relationship between flow (X) and pressure loss (Y) across the polypropylene hollow fiber oxygenator (1.6M
2) fit to a linear expression Y=A+BX (r=0.99) when it was perfused with water. B showed high correlation (r=0.99) to actual water viscosity η(B=-3.7+40.0η). Water viscosity η
* calculated from Poiseuille's law was close to η(η
*=0.26+1.32η, r=0.99). The pressure flow relationship about human blood (Ht 18%) also fit to a linear expression and B showed high correlation to blood viscosity η
** which was measured by a rotational viscometer (B=0.5+28.9η
**, r=0.99). The blood viscosity can be estimated using this oxygenator during open heart surgery.
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T. TAKAYAMA, H. MATSUMOTO, K. YAGYU, T. YOSHITAKE, A. MIZUNO, K. ASANO
1983 Volume 12 Issue 2 Pages
453-456
Published: April 15, 1983
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Antiplatelet drugs (Dypiridamole, Ticlopidine) were orally given 7 days before operation. By these drugs, activation of platelets aggregation and the formation of microembolei on the surface of oxygenator were remarkably suppressed. Prior to cardiopulponary bypass, if the platelet function was beneficially suppressed, platelet aggregation, consumption, and the formation of microemboli during cardiopulmonary bypass were prevented and the platelet counts and function were preserved.
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[in Japanese]
1983 Volume 12 Issue 2 Pages
457
Published: April 15, 1983
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T. TSUJI, T. TAMURA, T. TOGAWA, H. KANEKO, J. NARUMI, K. SUMA
1983 Volume 12 Issue 2 Pages
458-461
Published: April 15, 1983
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The microporous polypropylene hollow fiber oxygenator (pore size 650Å) was used for monitoring blood gas (PO
2, PCO
2). The original gas channel was perfused with blood and monitor gas (air) was circulated in the closed circuit which connects inflow and outflow port of the fiber channel. The hydrophioized oxygenator and the microporous cellulose hollow fiber dialyzer(pore size 30Å) were used for monitoring pH in which monitor solution (saline) was circulated in stead of gas. PO
2, PCO
2 and pH measured with non-blood contact method showed close value to those of the blood.
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S. MATSUNOBE, Y. SHIMIGU, T. TERAMATSU, T. NISHIO, S. TONOMURA, F. YOS ...
1983 Volume 12 Issue 2 Pages
462-464
Published: April 15, 1983
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The mechanism of direct CO
2 excretion using commercially available hemodialyzers was examined ex vivo. CO
2 was excreted both in the form of CO
2 and HCO
-3. The excretion ratio of CO
2 and HCO
-3 was about 1:20 if a suitable dialyzer was selected. This result showed that acetate hemodialysis did not disturb blood pH because Henderson-Hasselbalch equilibrium was not changed by this methad. clinically this method was very effective to control post hypercapnic alkalosis state in the patients with chronic respiratory failure which is difficult to be controlled by conventional mechanical ventilation.
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M. OTANI, H. HIROSE, H. MATSUDA, S. NAKANO, K. KAKU, R. SHIRAKURA, M. ...
1983 Volume 12 Issue 2 Pages
465-468
Published: April 15, 1983
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The present study was de signed to examine the effect of ultraf iltration (U-F) on tissue water content in small intestine (TWC), in dog, during hemodilution cardiopulmonary bypass (CPB). Eight dogs were placed on 5 hours' PB. The loss of the circulating blood volume was compensated by adding lactated Ringer's solution to the perfusate as required to maintain the level in the reservoir. After the first 2 hours' CPB, five dogs (group I) underwent U-F with blood transfusion for 2 hours. The remaining three dogs (group II) did not receive U-F. After the first 2 hours, hematocrit (Hct), serum total protein (TP) and serum colloid oncotic pressure (COP) were reduced arid. TWC increased in both groups. The difference between serum COP and lymphatic COP in thoracic duct markedly decreased. For the second 2 hours, in group I, Hct, TP and serum COP were elevated and the difference in COP was enlarged. Simultaneous reduction in TWC was obtained. In group II, Hct, TP and serum COP remained low and TWC increased. The results suggested that U-F might be effective to prevent from increase of TWC during hemodilution CPB.
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S. ODAIRI, H. KAWAHARA, Y. ISHIKURA, H. YOSHIMATSU, M. MURAKAMI
1983 Volume 12 Issue 2 Pages
469-472
Published: April 15, 1983
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Many problems were noticed for valve replacement associated with esophageal varices. We evaluated hemodynamic effects of pulsatile ECC on portal hypertensive dogs. Hepatic flow was increased during partial bypass with PAD. This result was considered to be due to the improvement of cardiac function.
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N. WATANABE, T. SASAKI, K. OHHORI, T. ABE, H. ADACHI, R. KASHINO, S. K ...
1983 Volume 12 Issue 2 Pages
473-476
Published: April 15, 1983
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This study was designed to investigate the sequential changes of energy metabolism in hypertrophied left venticle (LV) during 3 hours extracorporeal circulation (ECC), especially from the view point of transmural differences and to simultaneously estimate the protective effect of pulsatile flow on the fibrillated myocardium of left ventricular hypertrophy (LVH) dogs. In conclusion, hypertrophied LVs were well protected in the subendocardium by means of pulsatile flow during ECC compared with steady flow.
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[in Japanese]
1983 Volume 12 Issue 2 Pages
477
Published: April 15, 1983
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S. ABE, T. MONZEN, S. KORA, M. IWATA, A. TAKAHASHI
1983 Volume 12 Issue 2 Pages
478-481
Published: April 15, 1983
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Extracorporeal systemic hyperthermia has drawn attention as an advanced cancer therapy in clinical. This study shows that the systemic hyperthermia with extracorporeal circulation (ECC) performed in healthy dogs at 41.5-43.0°C for 4-10 hours using the efficient heat exchanger made with multiple stainless tubings (effective area: 0.06m
2). Under the general anesthesia, ECC was conducted by use of a common femoral arteriovenous (AV) bypass and ECC flow rate was kept at 20-30ml/kg/min (approximately 1/3 cardiac output) during the circulation. The animals' temperatures were controlled within ±0.1°C accurately by changing the temperature of heat exchanger in manual mode. In order to increase the rectal temperature from 38.0°C to 41.5°C, it took 30 minutes in 46°C of heat exchanger (the high blood-heating method) and 45 minutes in 43°C of heat exchanger (the low blood-heating method) respectively. Hyperthermia induced the thrombocytopenia, but the degree of this thrombocytopenia was moderate under the low-blood heating method compared with the high blood-heating method. Extracorporeal systemic hyperthermia can be carried out safely under the low blood-heating method using the efficient heat exchanger.
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S. HAMABE, Y. IDEZUKI, M. HAMAGUCHI, H. MORIYA, H. KOMORIYAMA, T. NAGA ...
1983 Volume 12 Issue 2 Pages
482-485
Published: April 15, 1983
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Despite recent advances in diuretic therapy, some patients with cirrhosis resist to the medical treatment and develop intractable ascites. The usual methods for treatment of intractable ascites by reinfusion of ascites to the patient are unable to remove malignant cells. Therefore, the use of the therapeutic modality has been limited only to patients with cirrhosis of the liver. We have developed a new apparatus using membrane plasmaphresis “PLASMAX”. This appararus is able to remove malignant cells and have utilized this in 7 patients with intractable ascites in both malignancy as well as cirrhosis of the liver. Pyrexia occured in some patients, but subsided spontaneously or with administration of the usual ant ipiretics. Gastro-intestinal bleedings, pulmonary edema and severe infection were not observed throughout this treatment. The present study described a new system using membrane plasmaphresis “PLASMAX” for reinfusion of sterilized, cell-free and concentrated ascitc fluid.
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Y. SHIMIZU, K. TAMURA, H. KATO, T. TERAMATSU, T. HINO
1983 Volume 12 Issue 2 Pages
486-489
Published: April 15, 1983
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In order to examine the influence of the pore size of the mesh on the wound healing of the reconstructed trachea, we prepared heavy Marlex mesh (pore size is about 1100μ, polyethylene), fine Marlex mesh (pore size is about 300μ, polypropylene), and several kinds of polyethylene meshes whose pore size are 120, 260, 760, and 1570μ. Using these meshes, we performed patchgraft in the cervical trachea of dogs. The results of fine Marlex mesh and 260μ polyethylene mesh are best. In consideration of these results, we tried 8 cases of tubular graft using fine Marlex mesh with teflon yarns which were inserted as supporting rings. All of the cases are alive and the wound healing of them is good.
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H. TSUJIKAWA, S. NAKAJIMA, T. MAEDA, Y. OMOTE, Yl KUBO, N. SAMEJIMA
1983 Volume 12 Issue 2 Pages
490-493
Published: April 15, 1983
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We have investigated optimal extracellular matrix, optimal oxygen tension, oxygen supply system and effect of cell stimulating agents for Hollow-fiber cell culture system. Collagen coating surface and positive charged surface have best abilitity of cell attachment and proliferation. The Molt 4 cells were most stimulated by ATP administration.
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[in Japanese]
1983 Volume 12 Issue 2 Pages
494
Published: April 15, 1983
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T. ITAOKA, J. WADA, J. KEI, M. SASOU, M. YAMAGUCHI, Y. KASAGI, N. NAGA ...
1983 Volume 12 Issue 2 Pages
495-502
Published: April 15, 1983
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We have been developing a radio-paque medium with improved oxygen-supplying capacity by mixing a conventional medium (75% Urografin) with oxygen-carrying perfluorochemicals (35w/v% Fluosol-DA). In clinical studies, 16 cases have been subjected to selective coronary arteriography and in each of these cases a radiopaque medium mixed 35w/v% FDA (FDA content: 10%, iodine content: 260mg/mL) and a conventional radio-paque medium containing no FDA (iodine ion content: 260mg/mL) were used in selective coronary angiography. Sigma-ST values in left coronary arteriographies showed a significant difference (p&0.02) between both groups.
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M. KOZAKI, K. MIYAMOTO, I. TAMAKI, E. SAKURAI, M. TOKUCHI, S. SUGIE, M ...
1983 Volume 12 Issue 2 Pages
503-506
Published: April 15, 1983
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In 18 experiment 36 kidneys were perfused - one pulsatile (P) and one non-pulsatile (NP) in each pair, all kidneys showed good function after autotransplantation. On histological findings of preserved kidneys, there were plugging of fibrin in the glomerular capillary tufts, with slight thickening of the basement membrane, regardless of the pumping systems, although these morphologic alterations were moderate in P perfusion and minimal in NP. These morphologic changes were also found in arterioles in P perfusion. NP perfusion is less potentially damaging to the kidney.
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Y. INAGAKI, Y. YAMASHITA, S. OHSHIMA, T. FUJITA
1983 Volume 12 Issue 2 Pages
507-510
Published: April 15, 1983
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We investigated the effect of continuous gastric cooling for supplementary cooling method using unsterilized fluid beside pomping fluid to the aorta. In a spine position, left (lt) kidney was cooled more than right (rt) one. But in rt lateral position, the cooling rate of the rt kidney was improved. Both rt and It kidneys were cooled to 15-20°C in the irrigation flow of 30ml/kg/min and 10-15°C in the irrigation flow of 50ml/kg/min. Based on these data, we investigated two types of balloon catheter. Continuous gastric cooling can be done with city water and unsterilized dialysate. This method could minimize intra-cellular edema due to the long time irrigation.
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Y. INAGAKI, S. OHSHIMA, T. FUJITA
1983 Volume 12 Issue 2 Pages
511-516
Published: April 15, 1983
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It is important problem to minimize the warm ischemia after cardiac arrest, because it is not yet permitted to extirpate the kidneys on the base of brain death in Japan. One of the good meithods is thought the selective kidney irrigation using a 3-lumen, double-balloon catheter (3L-DBC). In this experiment, we investigated 4-lumen, and 5-lumen, DBC
5 in order to measure the pressure by a transducer and temperature with a thermosensor between the balloons through the lumens added to the 3L-DBC. It's possible to evaluate the efficiency of the cooling machine in the recirculation method using 5L-DBC. The degree of hemolysis becomes great as time elapses in the recirculation method using diluted blood.
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Y. INAGAKI, M. TSUYUKI, T. YAMAMOTO, S. SUGIYAMA, [in Japanese], [in J ...
1983 Volume 12 Issue 2 Pages
517-521
Published: April 15, 1983
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Flexible double-lumen catheter (FDL catheter) was designed as temporary blood access. It's necessary to obtain large quantity of flow (ml/min) that in the limited outside diameter of a catheter, the size of arterial line (A line) is to be larger than that of venous line (V line), also that the wall thickness of A line is to be thicker than that of V line. FDL catheter (12F) has been finally made after repeated trial production to meet two criteria: 1) maximum blood flow of A line is more than 300ml/min 2) the pressure of V line is below 100mmHg under the condition of 200ml/min. FDL catheter is made of silicone rubber and teflon tube is inserted into the inner side of the catheter to reduce the friction resistance between FDL catheter and guide wire. FDL catheter can be inserted into the inferior or superior vena cava by Seldinger method.
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Y. FUKUI, K. GONDA, M. ICHINO, H. ITOH, T. SAITOH, N. MURASE, S. HATAK ...
1983 Volume 12 Issue 2 Pages
522-525
Published: April 15, 1983
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A computer controlled preservation system of a kidney is described. A kidney is preserved under normothermic (30-37°C) and aceptic environment in the organ preservation box with a pulsatile blood perfusion. Blood components, pressure and flow are measured onliie automatically by computers. A viability of the kidney is analyzed based on the measured data. Blood perfusion flow as well as gas and drug infusion are under computer control to perform an optimum preservation environment. Nine experiments of dog kidneys were performed with one successful preservation.
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[in Japanese]
1983 Volume 12 Issue 2 Pages
526
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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H. KOBAYASHI, M. ODAKA, H. HIRASAWA, Y. OHTAKE, S. ODA, S. KOBAYASHI, ...
1983 Volume 12 Issue 2 Pages
527-530
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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The previous study from our laboratory has shown that the depression of RES is a major cause of sepsis, septic ARF and MOF. Since we considered that DHP would enhance the RES and would prevent the RES depression, we investigated that possible usefulness of DHP as an artificial RES for the treatment of sepsis, septic ARF and MOF. To investigate the usefulness of DHP as the artificial RES we performed DHP on septic rat model which was produced by us and was very close to the clinical condition among septic patients. The result of survival study was as follows. DHP group 53.5%, glass DHP group 37.5%, priming solution IV group 50.0% and control group 45.8%, respectively.
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M. YAMAMOTO
1983 Volume 12 Issue 2 Pages
531-533
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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The artificial liver support system using charcoal hemoperfusion, cuprophan membrane hemodialysis and plasma exchange using cellulose acetate hollow fiber (CAHF) has been developed and applied to patients with acute hepatic failure. 7 out of 35 patients with fulminant hepatic failure and all 5 patients with acute fatty liver of pregnancy were survived. Even in fatal cases of fulminant hepatic failure, the prolongation of survival time was shown to be possible by daily repeated charcoal hemoperfusion and plasma exchange. These clinical results indicated that this system daily repeated with charcoal hemoperfusion and plasma exchange were effective in treatment of acute hepatic failure.
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T. OKA, T. TANI, K. MATSUDA, T. HSHIMOTO, A. KOSUGI, Y. NAKANE, M. KOD ...
1983 Volume 12 Issue 2 Pages
534-537
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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Aminogram and blood chemistry were analyzed before and after plasma exchange, charcoal direct hemoperfusion and charcoal plasmaperfusion. They are better to be performed with BCAA rich solution. Twelve adsorbents were studied how much substance they adsorbed in the batch mehtod. Bead activated carbon is one of the best adsorbents that are used clinically now, for the removal of bilirubin in DHP and PP.
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T. TAKAHAMA, I. IIZUKA, F. KANAI, M. HIRAISHI, K. YABE, Z. YAMAZAKI, K ...
1983 Volume 12 Issue 2 Pages
538-541
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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We studied the effect of continuous plasma cross circulation (systemic-portal) between totally hepatectomized dogs and donor dogs using two polymethylmethacrylate (PMMA) plasma separators. (“PLASMAX”) The specific purposes of this work were (1) to evaluate the possible effect of plasma exchange in acute hepatic failure and (2) to clarify the efficiency of systemic-portal plasma cross circulation.
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I. AMANO, U. INAGAKI, M. MIZOGAMI, H. KANOH
1983 Volume 12 Issue 2 Pages
542-545
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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Hepatic assists such as charcoal hemoperfusion and plasmapheresis were performed in 50 patients with acute liver failme, and 9 were survived. Several conditions in the beginning of treatment in survived patients were compared with them in died patients. Successful therapy of acute liver failme is to try to treat patients in early stages below 150mg per deciliter of plasma total aminoacicls levels.
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T. HORIUCHI, O. OTSUBO, T. INOU
1983 Volume 12 Issue 2 Pages
546-550
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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This study is development of the evaluation method for hepatic support system using normal subjects. Ischemic dog plasma (IDP), anhepatic dog plasma (ADP) and liver extract were injected into normal dogs intravenously with and without prior perfusion thru adsorbents. These injection tests indicate that substances derived from a damaged liver might attck the normal liver, and removability for toxic substances can be deduced histologically as well as biochemically by this method.
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[in Japanese]
1983 Volume 12 Issue 2 Pages
551
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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M. KIKUCHI, M. NISHIYAMA, M. IMURA, O. TAKATANI, Y. SUGIURA, T. OGATA, ...
1983 Volume 12 Issue 2 Pages
552-555
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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Almost all glucose control systems developed by several groups have adopted similar feedback control algorithms for delivery of insulin and glucose, which are based on the glucose concentration and its derivative component. However, parameters in controllers should be empirically specified. The main purpose of this paper is to develop an adaptive glucose control system via selftuning regulator, in which the blood glucose can be decreased from an initial high level in accordance with the desired profile specified by a doctor and can be maintained within narrow range even in cases of parametric variations in diabetic subjects and disturbances due to food intake.
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M. SHICHIRI, R. KAWAMORI, Y. GORIYA, N. HAKUI, Y. YAMASAKI, M. NOMURA, ...
1983 Volume 12 Issue 2 Pages
556-559
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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To evaluate the superiority of hydrogen peroxide(H
2O
2)-type electrode to oxygen(O
2)-type electrode as a glucose sensor, in vitro and in vivo experiments have been conducted. Minimal effect of change in O
2 tension on H
2O
2-type sensor's output indicated that our-developed needle-type glucose sensor using H
2O
2-type electrode could detect glucose concentration in sc tissue with least effect of change in O
2 tension
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S. IKEDA, K. ITO, S. SHIMIZU, M. UMENO, K. ICHIKAWA, T. YUKAWA, T. KON ...
1983 Volume 12 Issue 2 Pages
560-563
Published: April 15, 1983
Released on J-STAGE: October 07, 2011
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It is well known that PD-control system is useful for artificial β-cell. We tried to construct an analog PD-control system using OP Amps and C-MOS ICs. It consumes 8mW at ± 6.6V. Although a slight offset drift of sample-hold circuits was observed at mode exchange, the PD system was helpful to reduce the insulin infusion rate at decreasing periode of BGL in vitro test and animal experiments.
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