The effect of synthetic surfaces on intrinsic coagulation activities

Abstract

Blood coagulation activities have been measured on the surfaces of the synthetic materials including glass, plasticized polyvinylchloride (PVC), silicone rubber, hydrogel with long polyethyleneoxide chains (PEO), cationic hydrophilic polymer (PSD) and heparinized hydrophilic polymer (H-PSD). H-PSD effectively prevented the activation of the intrinsic coagulation factors by the complex formed between antithrombin III and heparin released from its surface. In the other materials, some differences in the activation of the intrinsic coagulation factors were found and discussed.