Abstract
The binding capacity of nafamostat mesilate (FUT) to dialysis membrane was studied in vitro and in vivo by using polyacrylonitrile(PAN), polymethylmethacrylate (PMMA) and cuprammonium cellulose (CC) membranes. FUT was adsorbed by PAN membrane in vitro and in vivo study. On the other hand, FUT was adsorbed by PMMA membrane in vitro study, but was not adsorbed by in vivo study. Furthermore, FUT was not absorbed by CC membrane in both studies. It is considered that FUT has a positive charge, so it was adsorbed by the negatively charged menbrane. PMMA membrane has thick protein layer in clinical use. It is therefore considered that FUT was not adsorbed by PMMA menbrane in vivo study.
