抄録
The purpose of this study is to elucidate the velocity of O2 and CO2 uptake and release of perfluorochemical (PFC) emulsion, which is a candidate for an artificial erythrocyte substitute because of its high O2 and CO2 solubility.
The velocity was measured with a polarographic continuous flow method and aa spectropnotometric stopped flow method.
These results were as follows:
1. The O2 uptake and rtlease of 20% PFC emulsion finished within 26msec., whose rate was more rapid than that of human erytnrocyte.
2. With a small quantity of carbonic anhydrase, the CO2 uptake and release of 5% PFC emulsion finished within 8, 5msec.
These results suggest that PFC emulsion may be useful as artificial O2 and CO2 carrier in circulation, i. e. artificial erythrocyte substitute.
