Abstract
Minimal heparin doses during hemodialysis was examined by the haparin sensitivity test and Gotch's Kinetic model using Whole Blood Partial Thromboplastin Time (WBPTT). WBPTT, which has a good correlation to Lee-White coagulation time, can be measured simply and rapidly with a small amount of blood. There is a linear relation between WBPTT and heparin concentration in vitro. Adequate heparin doses was 14.1u/B.W.kg, which was introduced by in vitro sensitivity test and 14.9u/B.W.kg by Gotch's method. There is a good correlation in between them. Heparin sensitivity test was not correlated with B. W., Ht, Platelet count. Dialysis could be done under the control of minimal heparization using these methods without increasing risk of patient bleeding and dialyzer clotting. We concluded that a precise of minimal heparinization with WBPTT is safer in the dialysis for high bleeding risk patients than the conventional method.
