抄録
Filters (membrane: ethylene vinylalcohol copolymer hollow fiber, surface area: 0.11m2) were implanted subcutaneously (inguinal) into 13 nonnephrectomized mongrel dogs. Three of them served for hemodynamic study. In the remaining 10, function of the filters, and a microscopic change of the membrane were followed up to 192 hours. Heparin was administered continuously using infusion pump. Two stage operation was selected to prevent hemorrage.
Just after implantation, ultrafiltrate obtained was 25.2±6.4ml/hour in the average. It decreased, however, to 17.0±7.9ml/hour at 24 hours, and 4ml/hour at 192 hours. The decrease of ultrafiltrate was explainable from clotting of peripheral hollow fibers. Fibers at the central part of the filters were free of thrombus. These results suggest a possibility of implanting a filter for blood purification.
