Evaluation study of inhaled oxygen concentration with combined use of ventilator and liquid oxygen in home oxygen therapy

抄録

This study explores the impact of leaks on the fraction of inspired oxygen (FiO₂) during noninvasive positive pressure ventilation (NPPV) with home oxygen therapy (HOT) in patients with chronic obstructive pulmonary disease (COPD). The study uses liquid oxygen instead of an oxygen concentrator typically used in HOT, and compares the results to a previous study. The study finds that while FiO₂ values decrease with increasing leaks, there is no statistically significant difference in the overall comparison, and there are no statistically significant differences for certain ventilation volumes. The study suggests that liquid oxygen may be more adequate for severely ill COPD patients, and provides meaningful results for target PaO₂ values in clinical practice. Limitations include the study being a basic experiment with simulated lungs, and further data collection is needed to compare the effects of oxygen concentrators on FiO₂ values.