抄録
Synthetic gastrointestinal hormones (VIP, GIP, Substance P and Bombesin) were infused at a dose of 20 pmol/kg/min for 10 min respectively.
Plasma IRI concentrations in the pancreatic vein and net release of insulin from the pancreas were significantly augmented during infusion of all of these peptides. The effect of substance P on IRI release was the most remarkable and its effect was transient compared with those of other peptides.
Plasma IRG concentration and net release of glucagon from the pancreas were also stimulated by VIP, substance P and GIP. However, bombesin did not increased glucagon secretion from the pancreas, but stimulated gut glucagon-like immunoreactivity.
These results indicate that many gastrointestinal hormones may play a role at the regulation of insulin and glucagon secretion through the specific action respectively.
