抄録
The two major factors associated with the development of peptic ulcer diseases are H. pylori infection and NSAID (non-steroidal anti-inflammatory drug). It has been made clear that various genetic polymorphisms are involved in the pathogenesis of peptic ulcer diseases, such as polymorphisms in the immune responses to H. pylori infection, those in virulence factors of H. pylori, those in the metabolism of NSAIDs including aspirin, and those in the mucosal defense system. There are also various polymorphisms in the therapeutics of peptic ulcer disease. How to apply this genetic information to clinical practice is the important theme.
