Strgigolactones (SLs) were initially characterized as host-derived chemical signals that induce seed germination of root parasitic plants. They were then recharacterized as symbiotic signals for arbuscular mycorrhizal fungi that supply inorganic nutrients such as phosphate to the host plants. In 2008, it was demonstrated that SLs act as plant hormones that regulate shoot branching. After the discovery of the hormonal function of SLs, there have been much progress in the SL research field. In this review we will introduce the latest knowledge on the SL perception and its signaling mechanism. DWARF14 (D14), which was characterized to be the SL receptor, is belonging to the α/β-hydrolase superfamily, and actually it can hydrolyze the SL molecules. Thus, there have been discussions about the relationships between the hydrolase activity and the signal transducing function of D14. We introduce several signaling models reported so far with a focus on this point.