婦人科腹腔鏡手術に伴うPONVに対するデキサメタゾン・ドロペリドールの改善効果の検討

抄録

Objective: Laparoscopic gynecological surgery is associated with a high incidence of PONV. In this study, we comparatively investigated the efficacy of combination therapy with dexamethasone plus droperidol versus no therapy in the prevention of PONV following laparoscopic gynecological surgery.

Design: In total, 122 patients who underwent laparoscopic gynecological surgery under general anesthesia at our institution from November 2017 to February 2018 were included in the study and assigned to two groups: the dexamethasone plus droperidol group (n=44) and the control group (n=78). Dexamethasone 6.6 mg was administered after the induction of anesthesia, and droperidol 1.25 mg was administered at the end of the surgery. The incidence of PONV and doses of administered rescue antiemetics were recorded on the first postoperative day.

Results: Combination therapy significantly reduced PONV compared with no therapy and required less rescue antiemetic treatment (P<0.05). No clinically important adverse effects were observed in either group.

Conclusion: Pretreatment with dexamethasone plus droperidol is more effective than no therapy in preventing PONV following laparoscopic gynecological surgery.