The purpose of this paper is to examine the significance of career orientation in knowledge worker’s career self-reliance. In recently years, new concepts of career development such as Boundaryless career, Protean career, and Career self-reliance are discussed in the context of increasing of knowledge workers. And self-concept such as career orientation is recognized as the foundation of their career development. Based on survey researches in 359 Japanese knowledge workers, this paper clarifies their career orientations have positive effects to their learning, performances, and job satisfactions. The most important finding is that combined career orientations enrich knowledge worker’s learning and improve their performances and job satisfactions.