This study assesses the impacts of climate, land use and population changes on water resources in the Srepok River basin. Based on the results of AGCM (JMA), rainfall was downscaled to generate the daily rainfall series. Land use change was quantified using a GIS-based logistic regression method. These changes were then input into the calibrated hydrological model to project hydrological variables. The results reveal that surface runoff will be increased with increased future rainfall while population growth has a slight impact on decreased water availability. Land use change has the largest impact on increased water demand, and thus reduced water availability.