Projection of river discharge in Indochina Peninsula region under a changing climate was carried out using flow routing model 1K-FRM and MRI-AGCM3.2S dataset. The impacts of climate change on river discharge in the region were investigated by comparing projected discharge corresponding to three climate experiment: the present climate (1979-2008), the near future climate (2015-2044) and the future climate (2075-2104). In addition, statistical tests were also applied to examine the statistical significance of river discharge changes in the region.