抄録
Liposomes have been used in animals as a good carrier for several drugs. However, problems with liposomal therapy are instability of liposome and lack in clinical use. Lipid particles, which are very stable and in widespread use for parenteral nutrition in man (intralipid), are also taken up readily by phagocytic cells like liposome. The present study was undertaken to investigate whether or not both IgG coated and non-coated lipid particles can be a good carrier for various drugs. The tissue distribution of lipid particles was studied by electromictoscopy and fluorescent microscopy. The lipid particles were easily phagocytized by macrophage of the liver, spleen and abdominal cavity, but not by neutrophils. On the other hand, IgG coated lipid particles were phagocytized by both of macrophage and neutrophils. Free dexamethasone phosphate exerted little influence on phagocytosis of IgG coated latex by macrophage, while lipid particles containing dexamethasone palmitate markedly suppressed the phagocytosis. This study suggests that IgG coated and non-coated lipid particles can be used as a drug carrier for various fat-soluble drugs.
