In academic fields requiring a high level of expertise, such as mathematics, information science, and nursing, effectively acquiring and applying knowledge is critical. Thus, in such academic fields, learning with awareness of body of knowledge—representing interrelationships between pieces of knowledge—is considered essential. The aim of this study is a development of a learning support system that can produce knowledge acquisition and knowledge utilization in an integrated manner using body of knowledge implemented in an information system (hereafter, a knowledge map). For knowledge acquisition, learning materials are associated with corresponding pieces of knowledge in a knowledge map, thereby learners can use the knowledge map in their learning. For knowledge application, we have adopted learning via question making. By asking learners to make questions with reference to the knowledge map, they become aware of the body of knowledge more systematically. The system was applied to the nursing process class, a core part of nursing education. We examined the effects of the system and found the use of system increased the ratio of learners’ understanding for the body of knowledge.