CD5-Positive Diffuse Large B Cell Lymphoma Infiltrating the Central Nervous System Presenting Guillain-Barré-Like Syndrome after Chemotherapy

Hisanori Machida; Tsutomu Shinohara; Nobuo Hatakeyama; Yoshio Okano; Mayuri Nakano; Makoto Tobiume; Keishi Naruse; Yoshihito Iwahara; Fumitaka Ogushi

doi:10.3960/jslrt.52.199

Case Study

CD5-Positive Diffuse Large B Cell Lymphoma Infiltrating the Central Nervous System Presenting Guillain-Barré-Like Syndrome after Chemotherapy

Hisanori Machida, Tsutomu Shinohara, Nobuo Hatakeyama, Yoshio Okano, Mayuri Nakano, Makoto Tobiume, Keishi Naruse, Yoshihito Iwahara, Fumitaka Ogushi

著者情報

キーワード: CD5-positive lymphoma, Guillain-Barré syndrome, diffuse large B cell lymphoma, Asian variant of IVL, cell surface marker

ジャーナルフリー

2012 年 52 巻 3 号 p. 199-204

DOI https://doi.org/10.3960/jslrt.52.199

詳細

抄録

An 83-year-old woman was admitted to our hospital with abdominal pain. Examination revealed mediastinal lymphoadenopathy, hepatosplenomegaly, and infiltration of abnormal cells into the bone marrow with hemophagocytosis, and CD5-positive diffuse large B cell lymphoma was diagnosed. Chemotherapy was administered and progressive weakness of the limbs, resembling a Guillain-Barré-like syndrome, subsequently appeared. Cerebrospinal fluid examination indicated lymphoma cell infiltration. Although immune globulin and steroid therapies were not effective, intrathecal injection of methotrexate, predonisolone, and cytarabine improved these symptoms. Subsequent to chemotherapy, cell surface antigen changes were observed in the cerebrospinal fluid relative to those in bone marrow. [J Clin Exp Hematopathol 52(3) : 199-204, 2012]

責任著者(Corresponding author)

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