Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
ISSN-L : 1346-4280
Case report
Acute fibrinous and organizing pneumonia following hemophagocytic syndrome in two adult patients with hematological malignancies
Satoru NannoHideo Koh Hiroshi OkamuraMitsutaka NishimotoYasuhiro NakashimaMasahiko OhsawaMasayuki HinoHirohisa Nakamae
ジャーナル オープンアクセス

2021 年 61 巻 2 号 p. 93-96


Acute fibrinous and organizing pneumonia (AFOP) is a rare acute lung injury featuring pathological intra-alveolar fibrin balls and organizing pneumonia without hyaline membranes or eosinophils. AFOP forms acute and subacute patterns; the former often has a poor prognosis, whereas the latter has better survival. Secondary hemophagocytic syndrome (HPS) is a cytokine-related and potentially lethal disorder induced by various diseases, and pulmonary involvement in HPS is not rare. However, to our knowledge, no report has addressed the association between secondary HPS and AFOP development. We report two cases of subacute AFOP following HPS in hematological malignancies.

© 2021 by The Japanese Society for Lymphoreticular Tissue Research

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