Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
ISSN-L : 1346-4280
Case report
Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma
Yoshiki FurukawaJun AndoMiki Ando Shintaro KinoshitaYoko EdahiroTakuya FurutaKoichi OhshimaNorio Komatsu
ジャーナル オープンアクセス

2021 年 61 巻 3 号 p. 168-172


Diffuse large B cell lymphoma (DLBCL) is an aggressive disorder accounting for >30% of all lymphomas. Its prognosis is poor due to a high relapse rate. Spontaneous regression (SR) in DLBCL is rare, with only a few reported cases. Moreover, almost all of these were low-grade lymphomas with an average SR duration of 13 mo. As the cause of SR is unknown, there are many theories such as trauma, infection, medication, and an antitumor immune response. We present a patient with progressive DLBCL who demonstrated SR for >42 mo. Although treatment for lymphoma usually starts soon after diagnosis, insights into SR of lymphomas may lead to new treatment strategies.

© 2021 by The Japanese Society for Lymphoreticular Tissue Research

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