We studied surface markers expressed in 58 cases of lymphoma of the skin except ATLL by immunohistochemical staining, using the ABC (avidin-biotin peroxidase complex) and PAP (peroxidase-antiperoxidase complex) methods. 40 cases were T cell lymphoma, 10 cases were B cell lymphoma and 8 cases were non-T non-B lymphoma. 36 cases of T cell lymphoma showed a helper/inducer phenotype (CD4+ CD8-), 2 cases showed a suppressor/cytotoxic phenotype (CD4- CD8+), 1 case showed CD4+ CD8+, and 1 case showed CD4- CD8-.
All 32 cases of mycosis fungoides showed 4B4+, 2H4-, UCHL-1+, Leu8-, Leu9-. 5 cases of these were analyzed on the reactivity to LFA-1 and VLA-4α, and all 5 cases showed LFA-1+, VLA-4α+.
Correlation with clinical stage of T cell lymphoma and expressions of each surface marker on lymphoid cells indicated fewer positively stained cells by CD1, CD7, Leu8, HLA-DR and HLA-DQ monoclonal antibodies in the advanced clinical stage.
