Innovative peritoneoscopic methods for treatment of gallstones fail to deal with the underlying problem of an abnormal gallbladder but do result in a rapid return by the patient to preoperative function. Peritoneoscopic laser cholecystectomy was developed in an attempt to create a minimally invasive yet definitive method of dealing with cholecystitis and cholelithiases. The method, as developed in the canine model under laparotomy was presented. It involves Nd-YAG laser and Surgiclip®technology under general anesthesia.