We investigated the time course of Hematoporphyrin oligomer (HpO) uptake after intraperitoneal (i. p.)-injection to squamous cell carcinoma (SCC) transplanted into C3H mice by measuring of the relative fluorescence intensity. The intensity was maximum at 83 hr after the i. p.-injection.
Furthermore, we investigated the therapeutic effect of photodynamic therapy (PDT) or microwave hyperthermia at varying time intervals after HpO i. p.-injection. The effect was strongest at 83 hr after the i. p.-injection in each therapy. And the sensitization effect of HpO by microwave action was clarified in vivo.
