Using nude mice bearing transplanted tumor of a KK-47 human bladder cancer, the effects of photodynamic therapy (PDT) with Al-phthalocyanine (AlPC), In-phthalocyanine (InPC) and Ga-phthalocyanine (GaPC) were compared. Photodynamic effects were evaluated as the tumor growth curves. For tumor control, the following efficies were found: AlPC>InPC>GaPC.
And PDT effect with AlPC and laser light at 670nm were compared with that ofAlPC and laser light at 630nm, and that of hematoporphyrin derivative (HpD) and laser light at 630nm. The regression of tumor volume after PDT was more with AlPC and laser light at 670nm than with AlPC and laser light at 630nm, and with HpD and laser light at 630nm.
These results suggest that AlPC may be promicing photosensitizer for PDT in respect of the tumor destruction.
