To get a locally destroyed cochlea of a guinea pig, the Nd-YAG laser was applied as the instrument. Before the animal experiments, following basic experiments were performed, 1) how the permeability of the Nd-YAG laser to bony-tissue is, compared with the argon laser. 2) how much the temperature is, at the irradiated portion in aqua.
According to the results of these basic experiments, a laser of adequate power and time was irradiated to the cochlea of the guinea pig. And then, extremely localized destructions of the inner and outer hair cells were produced.