Accumulation of HpD and NPe6 as photosensitizer in atheroma, by the fluorescence of HpD and NPe6, were demonstrated. HpD or NPe6 were given to atheromatous rabbits. The accumulative patterns of HpD and NPe6 in the atheroma were observed. The localization of HpD and NPe6 were examined by fluorescence spectrum detector. Characteristic emission of HpD and NPe6 fluorescence with peak of 630,690 and 670nm wavelength were detected in the atheroma. The thickness of the intima and the height of the spectra had correlation. It was suggested that the analysis of fluorescent spectrum might be useful for identifying the atherosclerotic lesions.
