光感受性物質(PH-1126)の移植大腸癌マウスにおける組織集積性および光力学治療効果

抄録

We subcutaneously transplanted colon 26 cells into mice to producea tumorl cm in diameter. Next, we intravenously administered PH-1126 to the cancer-bearing mice at dose levels of 5 mg/kg, 10 mg/kg, and 20 mg/kg, then observed the degree of distribution and accumulation of PH-1126 at the tumor sites and the individual normal intestial sites 24, 48, and 72 hours after administration. In a comparative study on the accumulation of PH-1126 in the skin, duodenum, ileum, rectum, and colon 26-induced tumor, we noted accumulations in the small intestine and colon, and to a small degree, in the rectum. The greatest accumulation was in the colon 26-induced tumor.
Next, we intravenously administered PH-1126 to mice bearing 1cm-diameter tumor at dose levels of 5 mg/kg and 10 mg/kg. 48 hours after the administration, we carried out P.D.T. using a krypton-ion lasr. We observed the changes in mice over time after the laser radiation. We then made a comparison between the P. D. T. group and the control group. As a result, we were able to obtain the antitumoral and survival effects of PH-1126 and P. D. T. These results suggest that P. D. D.·P. D. T. together with the administration of PH-1126 is useful in treating cancer of the rectum.