1994 年 15 巻 Supplement 号 p. 313-318
Histopathological changes of the prostatic smooth muscle cells following transurethral balloon laser thermotherapy (TUBAL-T) were studied under light and electron microscopy. Transperineal needle biopsy of the prostate was carried out in six patients with symptomatic benign prostatic hyperplasia immediately, 3 days, 2 weeks and 4 weeks after TUBAL-T. Immediately after treatment, edematous changes occured in the prostatic stroma. Two-four weeks after treatment, prominent degenerative necrosis of the prostatic smooth muscle cells were clearly observed. Immunoenzymatic stains of desmin and heat shock protein (HSP) were performed. Two weeks after treatment, the prostatic smooth muscle cells showed a weak stain of desmin. A generation of HSP was observed in the prostatic smooth muscle cells 90 minutes after treatment. These findings indicate that TUBAL-T causes degenerative necrosis of the prostatic smooth muscle cells.
