抄録
The authors per for med PDT, without any hyper ther mic effects, using a diode laser and NPe6 in an implanted fibrosar coma in mice and achieved tumor therapeutic effects. In the present study, PDT was per 5 hours following the administration of 5.0mg/kg NPe6. With 50, 100, 150 and 200J/cm2, tumor cure rates were 20, 50, 70 and 90%, respectively. The ratio of the residual amount of NPe6 following 50, 100, 150 and 200J/cm2 laser exposure to no laser exposure were 73.4, 36.2, 22.1 and 15.9% compared with control group respectively. These results suggest that a certain increase of laser light dose reaching deeper layer of tumor caused an incr ease in per cent cure. In addition, the recurrence of tumor depends at least partially on the total laser light dose reaching deeper layers of tumors.
