抄録
Tumor therapeutic effects of PDT using NPe6 as a photosensitizer and diode laser as the light source on BALB/c mice bearing Meth-A fibrosarcoma were examined. The more dose and the shorter interval time, the better cure rates were obtained. To elucidate wether the cure rates correlate to the NPe6 concentration in plasma or in tumor, NPe6 levels were measured by HPLC analysis. In conditions with plasma or tumor NPe6 concentration of nearly 0, PDT was performed and cure rates were obtained. As the results, difference of cure rates seemed to depend on the NPe6 concentration in plasma rather than in tumor. Therefor tumor therapeutic effects using NPe6 can be anticipated by the plasma NPe6 concentration at the time of PDT treatment.
