Studies with KTP/YAG Surgical Laser System and Nd-YAG laser were performed. In fundamental study,the effect of KTP laser was examined by using of extirpated uteri and compared with other laser sources.The vaporizing ability by KTP was in the midist of YAG and CO2 laser. The degenerated layer formed by KTP was similar to that by YAG. In clinical study with KTP/YAG laser, twenty-six with dysplasia or CIS, and one with questionable microinvasive cancer were treated at outpatient basis under local anesthesia. Laser conization was used in all cases. The primery cure rates of dysplasia and CIS were 100% and 92.3%,respectively.Concerning side effects, slight pain and hotness were only complained. Cervical stenosis was experienced in two cases. With Nd-YAG laser, sixteen caes with mild dysplasia, six cases with moderate dysplasia, three cases with severe dysplasia, seven cases with CIS and three cases with microinvasive cancer were treated under local anesthesia by hospitalization.Vaporization was used for eight cases with dysplasia and conization was usde for other cases. The primary cure rates were 100% in each case. Complications during and post operation were minimal. Conizated specimens were placed to examine HPV-DNA by means of PCP method. Primers for HPV types 16, 18, 31, 33, 35, 52b, 58 (M type) and types 6, 11 (B type) were used. We detected M type HPV in 1 case of 4 mild dysplasias, 1 case of 4 moderate dysplasias, 5 cases of 11 severe dysplasias, 6 cases of 19 CISs, and B type IIPV in 2cases of 4 moderate dysplasias, 4 cases of 11 severe dysplasias and 5 cases of 19 CISs. There was no significant differenses however, in the detection of HPV DNA between the results with and without the positive lesion on the edge of conizated specimens.
