抄録
Argon laser photo-chemotherapy with HpD has resulted in complete response in all of four patients with stomach and rectum carcinomas. At 72 hours after the administration of 2.5-3.0 mg/ Kg HpD intravenously, Argon laser beam with 0.4-1.5W, for 25- 50 min, was irradiated to the neoplastic lesions. Tumor regression was observed rapidly on the lesions with tissue necrosis within 24 hours after the treatment. The laser-induced ulceration was clearly demarcated from the surrounding normal mucosa. Complete disappearance of the tumor mass observed macro- and microscopically in a case with early rectal carcinoma. Invasive gastric cancers were also eradicated in three patients, but remained cancer cells were detected on repeated endoscopic biopsy. Since the present procedure give no influence to the immunological response of the body, a further laser treatment could be applied for total regression of neoplasm. Comparing with Nd: YAG laser treatment with a high energy, Argon laser photo-chemotherapy could be more effective as to tumor regression and less hazards. Because of applying the selective effect of HpD in the neoplastic cells, the procedure could be safely used in clinical medicine without surrounding normal mucosal damage.
